Prediction of Sodium Substitution Sites in Octacalcium Phosphate: The Relationships of Ionic Pair Ratios in Reacting Solutions

Octacalcium phosphate (OCP) is widely used in biomaterial fabrication by virtue of its unique crystal structure and low environmental loading. Although various ion molecule substitution methods into the OCP unit lattice have been introduced, it remains unclear which factors mechanisms dominate process. Experimental studies indicated that Na alkali metal ions are substituted at P3 PO4 conjugated site acidic to weakly conditions P5 neutral weak basic conditions. Ionic species calculation pair ratios HPO42− (NaHPO4−) small reacting solutions but large under Consequently, roles played NaHPO4− ionic formation processes thought lattice. Such strongly inhibits dicarboxylic acid due replacement Ca ion, conjugates as an anchor acid.